Mixed lymphocyte reaction in healthy women with rheumatoid factor. Lack of association with HLA-Dw4.

Abstract

In independent studies, 51% and 36% of patients with rheumatoid arthritis have been shown to possess HLA-Dw4 compared to 7% and 13% of controls. In one study Dw4 positive patients more frequently had rheumatoid factor in their sera than did Dw4 negative patients. In order to determine if the Dw4 specificity is associated with the disease or with the presence of rheumatoid factor, the frequency of this HLA antigen has been determined in 24 healthy women known to have rheumatoid factor (median titer 1:160). Only 3 were found to have the Dw4 specificity, suggesting that this specificity is not associated with rheumatoid factor in the absence of rheumatoid arthritis.

• Authors: E G Engleman, E E Sponzilli, M E Batey, S Ramcharan, H O McDevitt
• Journal: Arthritis and rheumatism (Arthritis Rheum) 1978 Jul-Aug Vol. 21 Issue 6 Pg. 690-3 ISSN: 0004-3591 [Print] United States
• PMID: 153750 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA Antigens
• Rheumatoid Factor

Topics

• Adult
• Arthritis, Rheumatoid (genetics, immunology)
• Female
• Genes, MHC Class II
• HLA Antigens (analysis)
• Humans
• Lymphocyte Culture Test, Mixed
• Lymphocytes (immunology)
• Middle Aged
• Rheumatoid Factor (analysis)