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Significance of non-erosive minimal esophageal lesions in gastro-esophageal reflux disorder.

AbstractBACKGROUND:
Non-erosive reflux disorder, which represents more than 60% of gastro-esophageal reflux disorders, lacks objective parameters for diagnosis. The purpose of this study was to evaluate the correlation between non-erosive minimal lesions at the lower esophagus and gastro-esophageal reflux disorder.
METHODS:
Patients were asked to answer a symptom questionnaire. The endoscopic findings were either graded by LA classification or recorded as non-erosive minimal lesions. Patients with minimal lesions were treated with rabeprazole or a placebo and responses were evaluated at weeks 1 and 4.
RESULTS:
In 8 centers, 3454 patients were screened. In patients with heartburn or acid regurgitation as the most bothersome symptom, 23.7% had endoscopy negative reflux disorder, 40.1% showed minimal lesions, and 36.20% had mucosal break esophagitis. Thirty-four percent of patients with minimal lesions and 39.1% of patients with LA 'grade A' mild esophagitis reported typical reflux symptoms as their main symptom. In patients with minimal lesions, medication with rabeprazole reduced symptoms significantly at weeks 1 and 4, but not with the placebo.
CONCLUSION:
Patients with non-erosive minimal esophageal lesions had similar reflux symptoms comparable to those with mild erosive reflux esophagitis, and reflux symptoms were improved with a short-term proton pump inhibitor. Thus, non-erosive minimal esophageal lesion constitutes a great part of gastro-esophageal reflux disorder.
AuthorsSung-Pyo Hong, Pil-Won Park, Seong-Gyu Hwang, Kwang-Hyun Ko, Sun-Young Kwak, Se-Hyun Kim, Kye-Sook Kwon, Yong-Woon Shin, Ji-Kon Ryu, Kwang-Hyun Ryu, Sang-Jong Park, Wook-Hee Won, Hyo-Min Yoo, Hyung-Mee Bae, Min-Jung Park, Yeol-Keun Woo, Kyung-Chul Kim, Kyung-Hee Kim, Seon-Hwa Na, Jung-Wan Kim
JournalThe Korean journal of internal medicine (Korean J Intern Med) Vol. 19 Issue 2 Pg. 93-8 (Jun 2004) ISSN: 1226-3303 [Print] Korea (South)
PMID15366639 (Publication Type: Controlled Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Benzimidazoles
  • Enzyme Inhibitors
  • Rabeprazole
  • Proton-Translocating ATPases
  • Omeprazole
Topics
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Ulcer Agents (therapeutic use)
  • Benzimidazoles (therapeutic use)
  • Enzyme Inhibitors (therapeutic use)
  • Esophageal Diseases (pathology)
  • Female
  • Follow-Up Studies
  • Gastroesophageal Reflux (drug therapy, epidemiology, pathology)
  • Humans
  • Korea (epidemiology)
  • Male
  • Middle Aged
  • Omeprazole (analogs & derivatives, therapeutic use)
  • Prospective Studies
  • Proton-Translocating ATPases (antagonists & inhibitors)
  • Rabeprazole
  • Treatment Outcome

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