| Abstract | BACKGROUND: Non-erosive reflux disorder, which represents more than 60% of gastro-esophageal reflux disorders, lacks objective parameters for diagnosis. The purpose of this study was to evaluate the correlation between non-erosive minimal lesions at the lower esophagus and gastro-esophageal reflux disorder. METHODS: Patients were asked to answer a symptom questionnaire. The endoscopic findings were either graded by LA classification or recorded as non-erosive minimal lesions. Patients with minimal lesions were treated with rabeprazole or a placebo and responses were evaluated at weeks 1 and 4. RESULTS: In 8 centers, 3454 patients were screened. In patients with heartburn or acid regurgitation as the most bothersome symptom, 23.7% had endoscopy negative reflux disorder, 40.1% showed minimal lesions, and 36.20% had mucosal break esophagitis. Thirty-four percent of patients with minimal lesions and 39.1% of patients with LA 'grade A' mild esophagitis reported typical reflux symptoms as their main symptom. In patients with minimal lesions, medication with rabeprazole reduced symptoms significantly at weeks 1 and 4, but not with the placebo. CONCLUSION: Patients with non-erosive minimal esophageal lesions had similar reflux symptoms comparable to those with mild erosive reflux esophagitis, and reflux symptoms were improved with a short-term proton pump inhibitor. Thus, non-erosive minimal esophageal lesion constitutes a great part of gastro-esophageal reflux disorder. |
| Authors | Sung-Pyo Hong, Pil-Won Park, Seong-Gyu Hwang, Kwang-Hyun Ko, Sun-Young Kwak, Se-Hyun Kim, Kye-Sook Kwon, Yong-Woon Shin, Ji-Kon Ryu, Kwang-Hyun Ryu, Sang-Jong Park, Wook-Hee Won, Hyo-Min Yoo, Hyung-Mee Bae, Min-Jung Park, Yeol-Keun Woo, Kyung-Chul Kim, Kyung-Hee Kim, Seon-Hwa Na, Jung-Wan Kim
(Affiliation: Department of Internal Medicine, Pochon CHA University, Bundang, Korea. sphong at cha.ac.kr)
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| Journal | The Korean journal of internal medicine
(Korean J Intern Med)
Vol. 19
Issue 2
Pg. 93-8
(Jun 2004)
ISSN: 1226-3303 Korea (South) |
| PMID | 15366639
(Publication Type: Controlled Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Ulcer Agents
- Benzimidazoles
- Enzyme Inhibitors
- rabeprazole
- Omeprazole
- Proton-Translocating ATPases
|
| Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adult
- Aged
- Aged, 80 and over
- Anti-Ulcer Agents
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Enzyme Inhibitors
(therapeutic use)
- Esophageal Diseases
(pathology)
- Female
- Follow-Up Studies
- Gastroesophageal Reflux
(drug therapy, epidemiology, pathology)
- Humans
- Korea
(epidemiology)
- Male
- Middle Aged
- Omeprazole
(analogs & derivatives, therapeutic use)
- Prospective Studies
- Proton-Translocating ATPases
(antagonists & inhibitors)
- Treatment Outcome
|
