Abstract |
This study aimed to investigate the binding affinity of [3H] GABA and [3H] beta-alanine to GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex (Brodmanns' area 9) in schizophrenia. Using post mortem tissue from individuals diagnosed with schizophrenia (n=6) and control subjects (n=6), the density of GAT-1 was established by displacing [3H] GABA with muscimol, and for GAT-3 [3H] beta-alanine was used. Data analysis showed a significant decrease of GAT-1 levels (45%), and a significant increase of GAT-3 density (23%) within the dorsolateral prefrontal cortex of individuals diagnosed with schizophrenia when compared to age- and sex-matched controls. The observed decrease of GAT-1 could be explained as a consequence of the GABA hypo-function or the result of volumetric shrinkage of the cerebral cortex previously reported in this disease. The observed elevation of GAT-3 levels could be due to a compensatory effect for any functional loss of GABA re-uptake by the decreased GAT-1 levels.
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Authors | Sonja B Schleimer, Tina Hinton, Gavin Dixon, Graham A R Johnston |
Journal | Neuropsychobiology
(Neuropsychobiology)
Vol. 50
Issue 3
Pg. 226-30
( 2004)
ISSN: 0302-282X [Print] Switzerland |
PMID | 15365220
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- GABA Plasma Membrane Transport Proteins
- Membrane Transport Proteins
- SLC6A1 protein, human
- SLC6A11 protein, human
- beta-Alanine
- gamma-Aminobutyric Acid
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Topics |
- Adult
- Autopsy
- Case-Control Studies
- Female
- GABA Plasma Membrane Transport Proteins
- Humans
- Male
- Membrane Transport Proteins
(analysis)
- Middle Aged
- Prefrontal Cortex
(physiology)
- Schizophrenia
(physiopathology)
- beta-Alanine
(pharmacokinetics)
- gamma-Aminobutyric Acid
(metabolism, pharmacokinetics)
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