An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population.

Abstract

We performed an association study between three SNPs in the genes of 14-3-3 family and paranoid schizophrenia. SNP rs983583 G/A in the YWHAZ gene showed significant association with paranoid schizophrenia. Our study indicated that the YWHAZ gene was a potential susceptibility gene for paranoid schizophrenia in the population studied.

• Authors: Yanbin Jia, Xin Yu, Boyu Zhang, Yanbo Yuan, Qi Xu, Yucun Shen, Yan Shen
• Journal: European psychiatry : the journal of the Association of European Psychiatrists (Eur Psychiatry) Vol. 19 Issue 6 Pg. 377-9 (Sep 2004) ISSN: 0924-9338 [Print] England
• PMID: 15363479 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA Primers
• Mixed Function Oxygenases
• tryptophan 2-monooxygenase
• Tyrosine 3-Monooxygenase

Topics

• Adult
• China
• DNA Primers (genetics)
• Enzyme Activation
• Female
• Gene Expression (genetics)
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• International Classification of Diseases
• Male
• Mixed Function Oxygenases (genetics)
• Neuropsychological Tests
• Polymerase Chain Reaction
• Polymorphism, Genetic (genetics)
• Polymorphism, Restriction Fragment Length
• Polymorphism, Single Nucleotide (genetics)
• Schizophrenia, Paranoid (diagnosis, ethnology, genetics)
• Tyrosine 3-Monooxygenase (genetics)