[Effects of ulinastatin on renal ultrastructure after ischemia-reperfusion in rats].

Abstract

OBJECTIVE:

To investigate the effect of ulinastatin on renal function and ultrastructure changes after renal ischemia-reperfusion in rats.

METHODS:

Acute ischemic renal injury model was established (45 min of bilateral renal ischemia and reperfusion for 24 h). Thirty Male SD rats were randomly divided into 3 groups: sham operation group (control group or group C, without renal ischemia), renal ischemia-reperfusion group (ischemia-reperfusion group or group I, without ulinastatin), renal ischemia-reperfusion and ulinastatin intravenous injection group (ulinastatin group or group U). BUN level, serum creatinine values and renal ultrastructure were measured.

RESULTS:

Serum creatinine (167 +/- 39) micromol/L and BUN concentration (21 +/- 7) mmol/L in group I were significantly higher than those in group U: serum creatinine (116 +/- 13) micromol/L and BUN concentration (14.1 +/- 2.6) mmol/L (P < 0.05). The renal ultrastructure was greatly injured in group I, meanwhile, it was obviously ameliorated in group U.

CONCLUSION:

Ulinastatin greatly improved renal function and provides remarkable protection on renal ultrastructure after ischemia-reperfusion of kidney in rats.

• Authors: Cong-cong Chen, Yan Zhou, Zi-ming Liu, Ju-mei Sun, Hui-hua Wang, Wei-dong Wu
• Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] (Zhonghua Wai Ke Za Zhi) Vol. 42 Issue 14 Pg. 877-80 (Jul 22 2004) ISSN: 0529-5815 [Print] China
• PMID: 15363281 (Publication Type: Journal Article)

Chemical References

• Glycoproteins
• urinastatin

Topics

• Animals
• Glycoproteins (pharmacology)
• Kidney (blood supply, drug effects, ultrastructure)
• Male
• Rats
• Rats, Sprague-Dawley
• Reperfusion Injury (drug therapy, pathology)