Abstract | BACKGROUND & AIMS: Inducible histamine and histamine H2-receptors have been suggested to be involved in innate immune response. METHODS: RESULTS: CONCLUSIONS: These findings as a whole indicated that endogenously produced histamine in Kupffer cells/macrophages plays a very important role in preventing excessive innate immune response in endotoxin-induced fulminant hepatitis through the stimulation of H2-receptors.
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Authors | Minori Yokoyama, Akira Yokoyama, Shuji Mori, Hideo K Takahashi, Tadashi Yoshino, Takeshi Watanabe, Takehiko Watanabe, Hiroshi Ohtsu, Masahiro Nishibori |
Journal | Gastroenterology
(Gastroenterology)
Vol. 127
Issue 3
Pg. 892-902
(Sep 2004)
ISSN: 0016-5085 [Print] United States |
PMID | 15362044
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-18
- Lipopolysaccharides
- Receptors, Histamine H2
- Tumor Necrosis Factor-alpha
- Histamine
- Interferon-gamma
- Histidine Decarboxylase
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Topics |
- Animals
- Female
- Gram-Positive Bacterial Infections
(complications, immunology)
- Hepatitis
(immunology)
- Histamine
(immunology)
- Histidine Decarboxylase
(immunology)
- Interferon-gamma
(immunology)
- Interleukin-18
(immunology)
- Lipopolysaccharides
(adverse effects)
- Liver Failure
(immunology, microbiology)
- Male
- Mice
- Mice, Knockout
- Models, Animal
- Propionibacterium acnes
- Receptors, Histamine H2
(immunology)
- Survival Analysis
- Tumor Necrosis Factor-alpha
(immunology)
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