Abstract | BACKGROUND AND PURPOSE: METHODS: A susceptibility surveillance of 267 isolates of Streptococcus pneumoniae, 205 of Streptococcus pyogenes, 204 of Haemophilus influenzae, and 147 of Moraxella catarrhalis to 14 oral antimicrobial agents using the agar dilution method was carried out from March 2002 to October 2002 in Taiwan. RESULTS: High rates of non-susceptibility to penicillin (60%), cefaclor (67%), cefuroxime (62%), cefpodoxime (64%), clarithromycin (91%), and trimethoprim-sulfamethoxazole (98%) for S. pneumoniae isolates and high rates of non-susceptibility to ampicillin (70%), clarithromycin (34%), and trimethoprim-sulfamethoxazole (63%) for H. influenzae isolates were found. The rank order of oral cephalosporin activity based on the minimum concentrations at which 90% of the isolates were inhibited (MIC90s) for S. pneumoniae was cefpodoxime > cefuroxime > cefixime > cefaclor, cephradine > cephalexin and for H. influenzae and M. catarrhalis was cefixime > cefpodoxime > cefuroxime > cefaclor > cephalexin, cephradine. Among the 75 S. pneumoniae isolates resistant to penicillin (MICs ranged 2 to 4 mg/L), 4% were intermediate to amoxicillin and > 90% were resistant to cefaclor, cefuroxime, and cefpodoxime. For S. pyogenes isolates, all were susceptible to penicillin, 21% were not susceptible to clarithromycin and 4% were not susceptible to clindamycin. Thirty four percent of H. influenzae isolates were not susceptible to clarithromycin. The MIC90 of clarithromycin against M. catarrhalis isolates was 0.5 mg/L. CONCLUSIONS:
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Authors | Po-Ren Hsueh, Wen-Kuei Huang, Jainn-Ming Shyr, Yeu-Jun Lau, Yung-Ching Liu, Kwen-Tay Luh |
Journal | Journal of the Formosan Medical Association = Taiwan yi zhi
(J Formos Med Assoc)
Vol. 103
Issue 9
Pg. 664-70
(Sep 2004)
ISSN: 0929-6646 [Print] Singapore |
PMID | 15361938
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Anti-Bacterial Agents
(pharmacology, therapeutic use)
- Community-Acquired Infections
(drug therapy, microbiology)
- Drug Resistance, Multiple, Bacterial
- Gram-Negative Bacteria
(drug effects)
- Gram-Positive Bacteria
(drug effects)
- Haemophilus influenzae
(drug effects)
- Humans
- Moraxella catarrhalis
(drug effects)
- Prospective Studies
- Respiratory Tract Infections
(drug therapy, microbiology)
- Streptococcus pneumoniae
(drug effects)
- Streptococcus pyogenes
(drug effects)
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