Severe factor X deficiency in pregnancy: case report and review of the literature.

Abstract

Isolate factor X deficiency is an extremely rare clotting factor disorder inherited in autosomal recessive fashion and pregnancy in a homozygous patient is frequently complicated by recurrent miscarriage, uterine bleeding and premature labour. Eleven pregnancies in seven patients affected by FX deficiency have been reported in the literature. Two additional pregnancies have been reported in a FX variant (FX Friuli). We present a new case of successful at term pregnancy in a homozygous patient.

• Authors: C Romagnolo, S Burati, S Ciaffoni, E Fattori, M Franchi, E Zanon, A Girolami
• Journal: Haemophilia : the official journal of the World Federation of Hemophilia (Haemophilia) Vol. 10 Issue 5 Pg. 665-8 (Sep 2004) ISSN: 1351-8216 [Print] England
• PMID: 15357794 (Publication Type: Case Reports, Journal Article)

Chemical References

• Prothrombin

Topics

• Adult
• Cesarean Section
• Factor X Deficiency (complications, therapy)
• Female
• Humans
• Postpartum Hemorrhage (prevention & control)
• Pregnancy
• Pregnancy Complications, Hematologic (therapy)
• Pregnancy Outcome
• Prothrombin (therapeutic use)