Abstract | OBJECTIVE: MATERIALS AND METHODS: New Zealand White rabbits (n=21) were divided into three groups. In the ischemia/reperfusion group (I/R) (n=8), the infrarenal aorta of rabbits was cross clamped for 21 min and then reperfused. In erdosteine group, the administration of erdosteine solution (50 mg/kg) was started two days before aortic cross-clamping and rabbits (n=8) were subjected to ischemia and reperfusion. Animals in control group (n=5) underwent a surgical procedure similar to the other groups but the aorta was not clamped. The animals were sacrificed at 72 h and histopathological, and biochemical analyses were carried out on the lumbar spinal cords. RESULTS: CONCLUSIONS: The present study demonstrated that erdosteine treatment before aortic cross clamping ameliorates neurological outcome, neuronal injury and oxidative stress in the rabbit spinal cord.
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Authors | E Ege, A Ilhan, A Gurel, O Akyol, S Ozen |
Journal | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
(Eur J Vasc Endovasc Surg)
Vol. 28
Issue 4
Pg. 379-86
(Oct 2004)
ISSN: 1078-5884 [Print] England |
PMID | 15350559
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers
- Expectorants
- Neuroprotective Agents
- Thioglycolates
- Thiophenes
- Nitric Oxide
- Malondialdehyde
- erdosteine
- Glutathione Peroxidase
- Superoxide Dismutase
- Xanthine Oxidase
- Adenosine Deaminase
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Topics |
- Adenosine Deaminase
(drug effects, metabolism)
- Animals
- Aorta, Abdominal
(metabolism, pathology)
- Biomarkers
(blood)
- Disease Models, Animal
- Expectorants
(therapeutic use)
- Glutathione Peroxidase
(drug effects, metabolism)
- Malondialdehyde
(metabolism)
- Models, Cardiovascular
- Motor Neurons
(drug effects, pathology)
- Neuroprotective Agents
(therapeutic use)
- Nitric Oxide
(metabolism)
- Oxidative Stress
(drug effects)
- Psychomotor Performance
(drug effects)
- Rabbits
- Reperfusion Injury
(complications, drug therapy, physiopathology)
- Spinal Cord
(metabolism, pathology)
- Spinal Cord Ischemia
(drug therapy, etiology, physiopathology)
- Superoxide Dismutase
(drug effects, metabolism)
- Thioglycolates
(therapeutic use)
- Thiophenes
(therapeutic use)
- Treatment Outcome
- Xanthine Oxidase
(drug effects, metabolism)
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