Struma Ovarii with a focus of papillary thyroid cancer: a case report and review of the literature.

Abstract

BACKGROUND:

Malignant Struma Ovarii is a rare ovarian neoplasm that is usually asymptomatic and infrequently diagnosed preoperatively. A few case studies have described associated thyrotoxicosis.

CASE:

A 46-year-old female presented for her annual gynecologic exam during which a pelvic mass was appreciated on physical examination. Patient was asymptomatic at presentation. A follow-up ultrasound confirmed the presence of a 16-cm mass in the right adnexa. Patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathology revealed a mature cystic teratoma with features of Struma Ovarii, containing a single 5-mm focus of papillary cancer within the thyroid tissue. Patient subsequently had a thyroid scan that was normal with normal thyroid function. There was no evidence of metastasis.

CONCLUSION:

Malignant Struma Ovarii is a very rare disease and there are various approaches to treatment based on staging. In our review, we found a higher rate of metastasis than previously reported. Recurrence was seen after an average period of 4 years. We recommend follow-up with surveillance thyroglobulin levels in cases of malignant Struma Ovarii for at least 10 years.

• Authors: Samina Makani, Wooshin Kim, Arthur R Gaba
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 94 Issue 3 Pg. 835-9 (Sep 2004) ISSN: 0090-8258 [Print] United States
• PMID: 15350384 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Carcinoma, Papillary (pathology, surgery)
• Female
• Humans
• Middle Aged
• Ovarian Neoplasms (pathology, surgery)
• Struma Ovarii (pathology, surgery)
• Thyroid Neoplasms (pathology, surgery)