[Hemodynamic and rheological effects of polyetox in rats with crush syndrome].

Abstract

Polyetox, a medicinal form of high-molecular-weight poly(ethylene oxide) (HMWPEO) improved peripheral blood supply, normalized the overall oxygen consumption, decreased erythrocyte aggregation, and reduced blood viscosity at low shear rate, and restored the antiturbulent properties (hydrodynamic index) of blood in the experiments on rats with crush syndrome. In rats with low resistance, polyetox increased the cardiac output.

• Authors: M B Plotnikov, G A Chernyshova, V I Smol'iakova, O I Aliev, T G Sutormina
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2004 May-Jun Vol. 67 Issue 3 Pg. 21-5 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Gemodinamicheskie i reologicheskie éffekty poliétoksa u krys s sindromom dlitel'nogo razdavlivaniia.
• PMID: 15341062 (Publication Type: Journal Article)

Chemical References

• Polyethylene Glycols

Topics

• Animals
• Blood Viscosity (drug effects)
• Crush Syndrome (blood, physiopathology)
• Erythrocyte Aggregation (drug effects)
• Hemodynamics (drug effects)
• Hemorheology (drug effects)
• Male
• Oxygen Consumption (drug effects)
• Polyethylene Glycols (pharmacology)
• Rats
• Regional Blood Flow (drug effects)