[Clinical observation of the curative effect of Qiangxin Mixture on congestive heart failure].

Abstract

OBJECTIVE:

To investigate the efficacy of Qiangxin Mixture in patients with congestive heart failure (CHF).

METHODS:

Sixty cases of CHF were randomly divided into Qiangxin Mixture group (treatment group, n=30) and digoxin group (control group, n=30). The total clinical effective rate, integra of the symptoms of kidney deficiency, classification of functional capacity of the New York Heart Association (NYHA), and echocardiogram [ejection fraction (EF), cardiac output (CO), interventricular septal thickness (IVST), posterior wall thickness (PWT), left ventricular mass index (LVMI)] as well as the measurement of plasma endothelin, angiotensin II and atrial natriuretic peptide were observed in both groups.

RESULTS:

The total clinical effective rate of Qiangxin Mixture group was 87%, and improvement was significantly observed in the Lee CHF score, classification of functional capacity of the NYHA, EF and CO (P<0.05, vs before treatment), but no significant improvement in digoxin group (P>0.05). The integra of the symptoms of kidney deficiency, the levels of plasma ET, Ang II and ANP decreased significantly (P<0.01, vs before treatment and digoxin group respectively). IVST, PWT and LVMI were also reduced significantly (P<0.01, vs before treatment; P<0.05 vs digoxin group).

CONCLUSION:

The Qiangxin Mixture is effective in enhancing cardiac contraction, improving hemodynamics in the short-term and rectifying some indexes in the long-term, so it could postpone the processes of CHF. This mechanism may be related to decreasing the stimulating factors (angiotensin, endothelin) which trigger the cardiac remodeling, delaying or reversing the cardiac remodeling.

• Authors: Zhao-Shan Chen, Yao-Rong Dong, Wan-Ying Hu
• Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao) Vol. 1 Issue 1 Pg. 25-9 (May 2003) ISSN: 1672-1977 [Print] China
• PMID: 15339608 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Drugs, Chinese Herbal
• qiangxin

Topics

• Aged
• Drug Combinations
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Heart Failure (drug therapy)
• Humans
• Male
• Middle Aged
• Phytotherapy
• Prognosis