[Effect of Xiangdan Injection on mRNA expression of endothelial vaso-active factors of patients with coronary heart disease and blood stasis].

Abstract

OBJECTIVE:

To evaluate the effect of Xiangdan Injection on mRNA expression of the endothelial vaso-active factors of patients with coronary heart disease and blood stasis.

METHODS:

Fifty-six patients were randomly divided into two groups:twenty-eight patients were treated according to the therapeutic guide for coronary heart disease as the control group and 28 were given the same treatment plus Xiangdan Injection as the treated group. The expressions of ET-1 and eNOS mRNA were examined with RT-PCR before experiment and ten days later.

RESULTS:

The positive rate of eNOS mRNA of the treated group increased, while the positive rate of ET-1 mRNA of the treated group decreased after ten day's treatment, with significant differences as compared with that before the experiment. Xiangdan Injection up-regulated the eNOS mRNA expression and suppressed the ET-1 mRNA expression. Changes of expression were not observed in the control group.

CONCLUSION:

Xiangdan Injection improves the endothelial function of patients with coronary heart disease and blood stasis by regulating the expressions of ET-1 and eNOS mRNA.

• Authors: Shi-Da Wu, Jing Wang, Shou-Chun Chen, Jun-Bo Xu, Qiang Zheng, Ya-Fei Yan, Tian-Ming Wen, Yan-Rong Tang
• Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao) Vol. 2 Issue 2 Pg. 94-6 (Mar 2004) ISSN: 1672-1977 [Print] China
• PMID: 15339465 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Endothelin-1
• RNA, Messenger
• Nitric Oxide
• NOS3 protein, human
• Nitric Oxide Synthase
• Nitric Oxide Synthase Type III

Topics

• Aged
• Aged, 80 and over
• Coronary Disease (drug therapy, metabolism)
• Coronary Thrombosis (drug therapy, metabolism)
• Endothelin-1 (genetics)
• Female
• Humans
• Injections
• Male
• Medicine, Chinese Traditional
• Middle Aged
• Nitric Oxide (biosynthesis)
• Nitric Oxide Synthase (genetics)
• Nitric Oxide Synthase Type III
• RNA, Messenger (analysis)