Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: The patient was a 15-year-old male adolescent with a history of schizoaffective disorder treated with ziprasidone capsules, 80 mg QD for 8 weeks prior to presentation. He was brought to the emergency department because the family noted that the child had a tactile fever; was rigid, diaphoretic, tremulous, and difficult to arouse; and had persistent urinary incontinence. The patient was admitted to the pediatric intensive care unit, where he remained rigid and unresponsive except for incoherent speech. He was treated for a presumptive diagnosis of NMS with IV dantrolene sodium (2 mg/kg q6h) to reduce the sequele of NMS; urinary alkalinization with sodium bicarbonate to maintain a urinary pH of 6.5 to 7.0; cardiac, pulse oximetry, and vital sign monitoring; and supportive care, including IV saline hydration. CONCLUSION: We present this case to alert physicians of the possibility of NMS in adolescent patients treated with ziprasidone.
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Authors | Joseph Leibold, Vipul Patel, Rashed A Hasan |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 26
Issue 7
Pg. 1105-8
(Jul 2004)
ISSN: 0149-2918 [Print] United States |
PMID | 15336475
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antipsychotic Agents
- Piperazines
- Thiazoles
- ziprasidone
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Topics |
- Adolescent
- Antipsychotic Agents
(adverse effects)
- Humans
- Male
- Neuroleptic Malignant Syndrome
(etiology, physiopathology)
- Piperazines
(adverse effects)
- Psychotic Disorders
(drug therapy)
- Thiazoles
(adverse effects)
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