The efficacy of interferon-alpha in a patient with resistant familial Mediterranean fever complicated by polyarteritis nodosa.

Abstract

Familial Mediterranean fever (FMF) is a recurrent self-limiting polyserositis. Polyarteritis nodosa (PAN) complicating FMF is very rare. Here, we present a 17-year-old male patient with FMF who subsequently developed PAN 2 weeks after hepatitis A infection. This case was also complicated with perirenal haematoma, and right nephrectomy was performed. The clinical condition of the patient was improved after therapy with intravenous and oral corticosteroid and intravenous cyclophosphamide. However, the FMF attacks and vasculitic skin lesions again occurred while he was using colchicine plus immunosuppressive agents a few months later. Interferon-alpha therapy was administered and the attacks were resolved within 3 months. He has not experienced any other symptom during the follow-up period of 28 months.

• Authors: Meral Calguneri, Sule Apras, Zeynep Ozbalkan, M Akif Ozturk
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 43 Issue 7 Pg. 612-4 (Jul 2004) ISSN: 0918-2918 [Print] Japan
• PMID: 15335192 (Publication Type: Case Reports, Journal Article)

Chemical References

• Interferon-alpha
• Colchicine

Topics

• Adolescent
• Angiography
• Colchicine (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Therapy, Combination
• Familial Mediterranean Fever (complications, diagnosis, drug therapy)
• Follow-Up Studies
• Humans
• Interferon-alpha (administration & dosage)
• Male
• Polyarteritis Nodosa (complications, diagnostic imaging, drug therapy)
• Risk Assessment
• Severity of Illness Index
• Tomography, X-Ray Computed
• Treatment Outcome