HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Comparative characteristics of immunological, clinical and morphological features of human lymphoid tumors in respect with tumor genesis and progression].

Abstract
We describe three lymphoid tumors with the same immunophenotype characteristic for chronic lymphoid leukemia (CD19+/CD5+, clonality of the light immunoglobulin chains, CD23+ and CD10-). However, clinical picture and morphology of neoplastic cells dictate different clinical forms of these cases: chronic lymphoid leukemia, large cell transformation of chronic lymphoid leukemia and diffuse large B-cell lymphoma. Taking into account that immunophenotype reflects the origin of tumor, while clinical outcome and morphological features of cells reflect the stage of tumor progression and/or pathway of tumor formation, we discuss the approach to natural classification of lymphoid tumors based on the process of their evolution.
AuthorsE M Gretsov, Zh V Churakova, E V Sheval', I A Vorob'ev
JournalOntogenez (Ontogenez) 2004 May-Jun Vol. 35 Issue 3 Pg. 229-38 ISSN: 0475-1450 [Print] Russia (Federation)
Vernacular TitleSravnitel'naya kharakteristika immunologicheskikh, klinicheskikh i morfologicheskikh priznakov limfaticheskikh neoplaziÄ­ cheloveka v sviazi s protsessami razvitiia opukholeÄ­.
PMID15334826 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antigens, CD19
  • CD5 Antigens
  • Receptors, IgE
  • Neprilysin
Topics
  • Antigens, CD19 (immunology)
  • B-Lymphocytes (immunology, pathology)
  • CD5 Antigens (immunology)
  • Flow Cytometry
  • Humans
  • Immunophenotyping
  • Leukemia, Lymphocytic, Chronic, B-Cell (immunology, pathology)
  • Light
  • Lymph Nodes (immunology, pathology)
  • Lymphoma, B-Cell (immunology, pathology)
  • Lymphoma, Large B-Cell, Diffuse (immunology, pathology)
  • Neprilysin (immunology)
  • Receptors, IgE (immunology)
  • Scattering, Radiation
  • Spleen (immunology, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: