Abstract |
We describe three lymphoid tumors with the same immunophenotype characteristic for chronic lymphoid leukemia (CD19+/CD5+, clonality of the light immunoglobulin chains, CD23+ and CD10-). However, clinical picture and morphology of neoplastic cells dictate different clinical forms of these cases: chronic lymphoid leukemia, large cell transformation of chronic lymphoid leukemia and diffuse large B-cell lymphoma. Taking into account that immunophenotype reflects the origin of tumor, while clinical outcome and morphological features of cells reflect the stage of tumor progression and/or pathway of tumor formation, we discuss the approach to natural classification of lymphoid tumors based on the process of their evolution.
|
Authors | E M Gretsov, Zh V Churakova, E V Sheval', I A Vorob'ev |
Journal | Ontogenez
(Ontogenez)
2004 May-Jun
Vol. 35
Issue 3
Pg. 229-38
ISSN: 0475-1450 [Print] Russia (Federation) |
Vernacular Title | Sravnitel'naya kharakteristika immunologicheskikh, klinicheskikh i morfologicheskikh priznakov limfaticheskikh neoplaziÄ cheloveka v sviazi s protsessami razvitiia opukholeÄ. |
PMID | 15334826
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Antigens, CD19
- CD5 Antigens
- Receptors, IgE
- Neprilysin
|
Topics |
- Antigens, CD19
(immunology)
- B-Lymphocytes
(immunology, pathology)
- CD5 Antigens
(immunology)
- Flow Cytometry
- Humans
- Immunophenotyping
- Leukemia, Lymphocytic, Chronic, B-Cell
(immunology, pathology)
- Light
- Lymph Nodes
(immunology, pathology)
- Lymphoma, B-Cell
(immunology, pathology)
- Lymphoma, Large B-Cell, Diffuse
(immunology, pathology)
- Neprilysin
(immunology)
- Receptors, IgE
(immunology)
- Scattering, Radiation
- Spleen
(immunology, pathology)
|