Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa.

Abstract

A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.

• Authors: Yoichi Nakao, Wesley Y Yoshida, Yuuki Takada, Junji Kimura, Liu Yang, Susan L Mooberry, Paul J Scheuer
• Journal: Journal of natural products (J Nat Prod) Vol. 67 Issue 8 Pg. 1332-40 (Aug 2004) ISSN: 0163-3864 [Print] United States
• PMID: 15332851 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antineoplastic Agents
• Peptides, Cyclic
• kulokekahilide-2

Topics

• Animals
• Antineoplastic Agents
• Drug Screening Assays, Antitumor
• Hawaii
• Inhibitory Concentration 50
• Leukemia P388
• Mice
• Molecular Conformation
• Molecular Structure
• Mollusca
• Peptides, Cyclic (chemistry, isolation & purification, pharmacology)
• Stereoisomerism
• Tumor Cells, Cultured