Abstract |
The patient was a 67-year-old man in whom hepatic metastasis from transverse colon cancer was detected 15 months after transverse colectomy (D2). We treated the patient by systemically administering 2 courses of 5-FU 750 mg/day with l-LV 350 mg/day (once weekly for 6 weeks per course). Assessment of therapeutic effects by CT showed PD in the patient. As a second-line therapy, we treated the patient by systemically administering 3 courses of 5-FU 750 mg/day, l-LV 350 mg/day and CPT-11 40 mg/day x 3 days (once a week for 4 weeks per course). After 3 courses of this chemotherapy, CT examination revealed a reduction in the tumor size of the liver, and CEA levels decreased at the end of this chemotherapy. This chemotherapy also showed no high-grade toxicities. l-LV/5-FU/low-dose CPT-11 seems to be effective for metastatic colon cancer, and safe from the toxicity standpoint.
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Authors | Osamu Harada, Makoto Kobayashi, Makoto Sasamoto, Sen Shimaya |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 31
Issue 8
Pg. 1245-7
(Aug 2004)
ISSN: 0385-0684 [Print] Japan |
PMID | 15332552
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Irinotecan
- Leucovorin
- Fluorouracil
- Camptothecin
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Topics |
- Adenocarcinoma
(drug therapy, secondary, surgery)
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives)
- Chemotherapy, Adjuvant
- Colectomy
- Colonic Neoplasms
(drug therapy, pathology, surgery)
- Drug Administration Schedule
- Fluorouracil
(administration & dosage)
- Humans
- Irinotecan
- Leucovorin
(administration & dosage)
- Liver Neoplasms
(drug therapy, secondary)
- Male
- Remission Induction
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