Abstract | BACKGROUND: METHODS: RESULTS: Preoperative FGF-23 levels correlated positively with phosphorus (P < 0.05), calcium- phosphorus product (Ca x P; P < 0.0005), and PTH values (P < 0.05). Serum FGF-23 levels decreased time dependently after PTX (P < 0.0005). Both serum phosphorus and Ca x P values decreased similarly after PTX ( P = 0.0001). Furthermore, FGF-23 levels days 1 and 3 correlated linearly with serum phosphorus (P < 0.05; P < 0.005, respectively) and Ca x P values (P < 0.01; P < 0.0001, respectively). CONCLUSION: FGF-23 levels correlate positively with serum phosphorus, Ca x P, and PTH values in patients with advanced secondary hyperparathyroidism. Complete ablation of progressive parathyroid glands reduces circulating FGF-23 levels, simultaneously decreasing serum phosphorus and Ca x P values. These findings suggest that hyperplastic parathyroid glands, together with hyperphosphatemia, affect abnormal FGF-23 metabolism in patients with stage 5 CKD with advanced secondary hyperparathyroidism.
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Authors | Tetsuhiko Sato, Yoshihiro Tominaga, Tsuneo Ueki, Norihiko Goto, Susumu Matsuoka, Akio Katayama, Toshihito Haba, Kazuharu Uchida, Shohei Nakanishi, Junichiro James Kazama, Fumitake Gejyo, Takeyoshi Yamashita, Masafumi Fukagawa |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 44
Issue 3
Pg. 481-7
(Sep 2004)
ISSN: 1523-6838 [Electronic] United States |
PMID | 15332221
(Publication Type: Journal Article)
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Chemical References |
- FGF23 protein, human
- Fibroblast Growth Factors
- Fibroblast Growth Factor-23
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Topics |
- Chronic Disease
- Female
- Fibroblast Growth Factor-23
- Fibroblast Growth Factors
(blood)
- Humans
- Hyperparathyroidism, Secondary
(blood, etiology, surgery)
- Kidney Diseases
(complications, therapy)
- Male
- Middle Aged
- Parathyroidectomy
- Renal Dialysis
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