Noncariogenicity of maltitol in specific pathogen-free rats infected with mutans streptococci.

Abstract

The effect of maltitol on caries development was examined in an experimental caries system employing specific pathogen-free (SPF) Sprague-Dawley rats. Fourteen strains of oral streptococci, including mutans streptococci, did not utilize the maltitol nor produce sufficient acid to demineralize tooth enamel. Furthermore, maltitol did not serve as a substrate for glucosyltransferases of either Streptococcus mutans MT8148R or Streptococcus sobrinus 6715 to synthesize water-insoluble glucan. Maltitol induced no significant dental caries in SPF rats infected with these mutans streptococci, and replacement of the dietary sucrose content with maltitol resulted in a trend towards caries reduction in SPF rats.

• Authors: T Ooshima, A Izumitani, T Minami, T Yoshida, S Sobue, T Fujiwara, S Hamada
• Journal: Caries research (Caries Res) Vol. 26 Issue 1 Pg. 33-7 ( 1992) ISSN: 0008-6568 [Print] Switzerland
• PMID: 1533175 (Publication Type: Journal Article)

Chemical References

• Cariostatic Agents
• Glucans
• Polysaccharides, Bacterial
• Sugar Alcohols
• Sweetening Agents
• Sucrose
• Maltose
• maltitol

Topics

• Animals
• Bacterial Adhesion
• Cariostatic Agents (metabolism, pharmacology)
• Dental Caries (etiology, microbiology)
• Dental Plaque (etiology, microbiology)
• Glucans (biosynthesis)
• Male
• Maltose (analogs & derivatives, metabolism, pharmacology)
• Polysaccharides, Bacterial (biosynthesis)
• Rats
• Rats, Inbred Strains
• Specific Pathogen-Free Organisms
• Streptococcus (metabolism)
• Streptococcus mutans (metabolism)
• Streptococcus sanguis (metabolism)
• Streptococcus sobrinus (metabolism)
• Sucrose (metabolism)
• Sugar Alcohols (metabolism, pharmacology)
• Sweetening Agents (metabolism, pharmacology)