Expression of dihydropyrimidine dehydrogenase in cancer cells but not in stromal cells predicts the efficacy of fluorouracil treatment in patients with gastric carcinoma.

Abstract

BACKGROUND:

It is not known whether immunohistochemical quantification of dihydropyrimidine dehydrogenase (DPD) in cancer cells, stromal mononuclear cells and normal glands predicts the efficacy of fluorouracil (FU) derivatives inpatients with T3 gastric adenocarcinoma.

MATERIALS AND METHODS:

The levels of DPD in cancer cells, stromal cells and normal glands were measured immunohistochemically in 111 patients with T3 gastric carcinoma. Adjuvant chemotherapy with oral UFT (uracil/tegafur[4:1]) was administered to 95 patients for more than 1 year after surgery.

RESULTS:

Forty-two (37.8%) patients demonstrated high DPD expression in the cytoplasm of their cancer cells. In patients with low DPD expression in cancer cells, the 5-year survival rates were 64.5% in patients given FU and 42.8% in those not given FU (p=0.014). Neither stromal cells nor normal glands affected the efficacy of FU treatment in relation to their DPD expression.

CONCLUSION:

DPD expression in cancer cells but not in stromal cells could be a predictor of the efficacy of FU chemotherapy in patients with T3 gastric carcinoma.

• Authors: Kazunori Hisamitsu, Shunichi Tsujitani, Kenichi Yamaguchi, Kenji Fukuda, Ichiro Konishi, Nobuaki Kaibara
• Journal: Anticancer research (Anticancer Res) 2004 Jul-Aug Vol. 24 Issue 4 Pg. 2495-501 ISSN: 0250-7005 [Print] Greece
• PMID: 15330204 (Publication Type: Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Tegafur
• Uracil
• Dihydrouracil Dehydrogenase (NADP)
• Thymidylate Synthase
• Fluorouracil

Topics

• Adenocarcinoma (drug therapy, enzymology, pathology, surgery)
• Antimetabolites, Antineoplastic (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, pharmacokinetics)
• Chemotherapy, Adjuvant
• Dihydrouracil Dehydrogenase (NADP) (biosynthesis, metabolism)
• Female
• Fluorouracil (pharmacokinetics, therapeutic use)
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Neoplasm Staging
• Stomach Neoplasms (drug therapy, enzymology, pathology, surgery)
• Stromal Cells (enzymology)
• Tegafur (administration & dosage, pharmacokinetics)
• Thymidylate Synthase (biosynthesis)
• Uracil (administration & dosage, pharmacokinetics)