Abstract | OBJECTIVES: METHODS: Eight males and seven females, mean age 48 years, with moderate to advanced periodontitis participated in the study. In each patient, bilateral periodontal pockets probing 6-7 mm were randomly assigned to treatment by Sc/Rp + doxycycline polymer or by Sc/Rp alone. Subgingival placement of doxycycline polymer was carried out according to the manufacturer's instructions. Sc/Rp was performed with hand instruments for at least 10 min in each study tooth. Subgingival samples were collected by paper-points at baseline, at 2 weeks and at 4 weeks post-treatment. Culture methodology was used to isolate and identify putative periodontal pathogens, including Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Dialister pneumosintes, Tannerella forsythia, Prevotella intermedia/Prevotella nigrescens, Campylobacter species, Eubacterium species, Fusobacterium species, Peptostreptococcus micros, Eikenella corrodens, Staphylococcus species, enteric gram-negative rods, beta-hemolytic streptococci and yeasts. The microbiologic examination was carried out blindly. Microbiological data were analyzed using a General Linear Model Analysis of Variance for within and between group effects. RESULTS: Sites receiving Sc/Rp + doxycycline polymer and sites receiving Sc/Rp alone exhibited similar levels of periodontal pathogens at baseline and did not differ significantly in total viable counts and proportional recovery of periodontopathic bacteria post-treatment. CONCLUSIONS: Controlled-release doxycycline placed in moderate to deep periodontal pockets caused no significant additional reduction in the subgingival pathogenic microbiota compared to thorough Sc/Rp alone. Since controlled-release doxycycline may not significantly suppress several subgingival pathogenic microorganisms and seems to possess no distinct advantage over broad-spectra, safe and inexpensive antiseptics, the rationale for its employment in periodontal therapy remains unclear.
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Authors | M G Jorgensen, A Safarian, N Daneshmand, R J Keim, J Slots |
Journal | Journal of periodontal research
(J Periodontal Res)
Vol. 39
Issue 5
Pg. 315-9
(Oct 2004)
ISSN: 0022-3484 [Print] United States |
PMID | 15324352
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Infective Agents, Local
- Delayed-Action Preparations
- Doxycycline
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Topics |
- Adult
- Aged
- Analysis of Variance
- Anti-Infective Agents, Local
(administration & dosage)
- Bacteria, Anaerobic
(drug effects)
- Colony Count, Microbial
- Delayed-Action Preparations
(administration & dosage)
- Dental Scaling
- Doxycycline
(administration & dosage, analogs & derivatives)
- Female
- Gram-Negative Bacteria
(drug effects)
- Humans
- Male
- Middle Aged
- Periodontal Pocket
(drug therapy, microbiology)
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