Abstract | BACKGROUND:
Chronic periodontitis causes a low-grade systemic inflammatory response; its standard treatment, however, induces an acute inflammatory response. The aim of this study was to describe the systemic inflammatory reactions to an intensive periodontal treatment regimen. METHODS: Fourteen otherwise healthy subjects suffering from severe chronic periodontitis were enrolled in a 1 month pilot single-blind trial. Intensive periodontal treatment, consisting of full-mouth subgingival root debridement delivered within a 6-h period, was performed. Periodontal parameters were recorded before and 1 month after completion of treatment. Blood samples were taken at baseline and 1, 3, 5, 7 and 30 days after treatment. Interleukin-1 receptor antagonist (IL-1Ra), Interleukin-6 (IL-6) and C-reactive protein (CRP) serum concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Complete blood counts were also performed. RESULTS: One day after treatment, mild neutrophilia and monocytosis (p < 0.05) and lymphopenia (p < 0.01) were accompanied by a sharp increase in inflammatory markers (IL-1Ra, IL-6, p < 0.01). A 10-fold increase in CRP (p < 0.001) was detected on day 1 and its kinetics followed a pattern of a classical acute phase response (significantly raised concentrations up to 1 week, p < 0.01). At 3-7 days after treatment, subjects presented also with a mild tendency towards a normocytic anaemic state (p < 0.01) and a degree of lympho- thrombocytosis (p < 0.05). The observed changes were similar to those expected following the well-characterized endotoxin-challenge model of inflammation. CONCLUSIONS: Intensive periodontal treatment produced an acute systemic inflammatory response of 1 week duration and might represent an alternative to classic endotoxin-challenge or drug-induced models to study acute inflammation in humans.
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Authors | F D'Aiuto, L Nibali, V Mohamed-Ali, P Vallance, M S Tonetti |
Journal | Journal of periodontal research
(J Periodontal Res)
Vol. 39
Issue 5
Pg. 294-9
(Oct 2004)
ISSN: 0022-3484 [Print] United States |
PMID | 15324349
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- IL1RN protein, human
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-6
- Sialoglycoproteins
- C-Reactive Protein
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Topics |
- Acute-Phase Reaction
(blood, etiology)
- Analysis of Variance
- Blood Cell Count
- C-Reactive Protein
(analysis)
- Chronic Disease
- Dental Scaling
(adverse effects)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-6
(blood)
- Male
- Middle Aged
- Models, Biological
- Periodontitis
(blood, therapy)
- Pilot Projects
- Prospective Studies
- Sialoglycoproteins
(blood)
- Single-Blind Method
- Statistics, Nonparametric
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