Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea.

Abstract

The effects of epimestrol (5 mg every 6 hours for 5 days) on basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (Prl), estradiol, progesterone, and dehydroepiandrosterone sulfate, and on the response to LH-releasing hormone (LH-RH) and thyrotropin-releasing hormone (TRH) stimulation, were studied in 18 cases of secondary amenorrhea and oligomenorrhea of hypothalamic-pituitary origin, in three cases of anorexia nervosa, in two cases of long-lasting progestin-induced amenorrhea, and in one case of precocious menopause. The results in the first 18 patients indicate that epimestrol treatment induces a significant increase in LH and Prl levels after 24 hours, while the FSH increase becomes significant only after 4 days of therapy. Twelve hours after discontinuation of treatment, all three hormone levels decreased significantly to values similar to the basal levels, while the pituitary response to LH-RH indicated a much more marked LH secretion than before treatment. A second test, performed 36 hours after the last drug administration, again showed a significantly higher LH response than that found under basal conditions. No significant variations were observed in the FSH response to LH-RH, nor in the Prl response to TRH. These data suggest that epimestrol interferes at the level of the centers responsible for Prl and gonadotropin secretion in the manner of a weak estrogen.

• Authors: A R Genazzani, F Facchinetti, V de Leo, E Picciolini, F Franchi, D Parrini, P M Kicovic
• Journal: Fertility and sterility (Fertil Steril) Vol. 30 Issue 6 Pg. 654-60 (Dec 1978) ISSN: 0015-0282 [Print] United States
• PMID: 153243 (Publication Type: Journal Article)

Chemical References

• Estrenes
• Gonadotropins, Pituitary
• Gonadotropin-Releasing Hormone
• Dehydroepiandrosterone
• Progesterone
• Estradiol
• Thyrotropin-Releasing Hormone
• Epimestrol
• Prolactin
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Adolescent
• Adult
• Amenorrhea (blood)
• Anorexia Nervosa (blood)
• Dehydroepiandrosterone (blood)
• Epimestrol (pharmacology)
• Estradiol (blood)
• Estrenes (pharmacology)
• Female
• Follicle Stimulating Hormone (blood)
• Gonadotropin-Releasing Hormone (pharmacology)
• Gonadotropins, Pituitary (blood)
• Humans
• Luteinizing Hormone (blood)
• Menstruation Disturbances (blood)
• Oligomenorrhea (blood)
• Progesterone (blood)
• Prolactin (blood)
• Thyrotropin-Releasing Hormone (pharmacology)