[Analysis of anti-microbial resistance of Escherichia coli that caused infection in urogenital system].

Abstract

OBJECTIVE:

To study the anti-microbial resistance of Escherichia coli (E.coli) that caused infection in urogenital system.

METHOD:

Anti-microbial susceptibility tests for 148 strains of E.coli were conducted by disc diffusion technique.

RESULTS:

In 28 commonly used antibiotics, the resistance rates of E. coli to beta-lactam and quinolones were high (73.6%-86.4%). High resistance rates to the first- and the second-generation cephalosporin (cefradime, cephazolin and cefaclor) were also observed (44%). Resistance rate to ceftazidime is the lowest (10.1%) in the third-generation cephalosporin. The resistance rates of E. coli to piperacillin, pefoperazone and ampicillin were 84.5%, 44.6% and 83.0% respectively. Combined antibiotic and beta-lactam inhibitor gave lower resistance rates than antibiotic alone (piperacillin/tazobactam, cefoporazone/sulbactam and ampicillin/sulbactam were 4.1%, 10.8% and 52.0% respectively, P<0.01). Of 148 E. coli isolates, 38 strains were capable of yielding extended-spectrum beta-lactamases (ESBLs) (25.7%), 110 strains were not able to produce ESBLs (74.3%) and the resistance rates of isolates with ESBLs to 28 antibiotics were significantly lower than those of isolates without ESBLs.

CONCLUSION:

Antibiotic/beta-lactam inhibitor and nitrofurantoin are effective for urogenital infections caused by E. coli.

• Authors: Wei-li Cui, De-xing Xu, Wen-ling Li, Lu-xia Wang
• Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA (Di Yi Jun Yi Da Xue Xue Bao) Vol. 24 Issue 8 Pg. 940-2, 945 (Aug 2004) ISSN: 1000-2588 [Print] China
• PMID: 15321769 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• Quinolones
• beta-Lactams

Topics

• Anti-Bacterial Agents (pharmacology)
• Cephalosporins (pharmacology)
• Drug Resistance, Bacterial
• Escherichia coli (drug effects)
• Escherichia coli Infections (microbiology)
• Humans
• Microbial Sensitivity Tests
• Quinolones (pharmacology)
• Urinary Tract Infections (microbiology)
• beta-Lactam Resistance
• beta-Lactams (pharmacology)