The role of serotonin in preeclamptic hypertension. A review and case report.

Abstract

Generalized arteriolar vasospasm and subsequent damage to vascular endothelium are fundamental to the development of preeclampsia. A possible mechanism underlying this involves increased deportation of trophoblast cells into maternal venous circulation with 5-hydroxytryptamine (serotonin, 5-HT) release as a consequence of platelet aggregation onto these fragments. Ketanserin, a 5-HT(2) receptor blocker, has been used successfully to treat preeclampsia. An examination of the therapeutic role of ketanserin indicates that there should now be a much more detailed assessment of serotonin antagonists in the treatment and prophylaxis of preeclampsia and eclampsia.

• Authors: C Hutter, I M Crighton, K Smith, D T Liu
• Journal: International journal of obstetric anesthesia (Int J Obstet Anesth) Vol. 5 Issue 2 Pg. 108-14 (Apr 1996) ISSN: 0959-289X [Print] Netherlands
• PMID: 15321364 (Publication Type: Journal Article)