Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.

Abstract

Extract of gum resin of B. serrata containing 60% acetyl 11-keto beta boswellic acid (AKBA) along with other constituents such as 11-keto beta-boswellic acid (KBA), acetyl beta-boswellic acid and beta-boswellic acid has been evaluated for antianaphylactic and mast cell stabilizing activity using passive paw anaphylaxis and compound 48/80 induced degranulation of mast cell methods. The extract inhibited the passive paw anaphylaxis reaction in rats in dose-dependant manner (20, 40 and 80 mg/kg, po). However, the standard dexamethasone (0.27 mg/kg, po) revealed maximum inhibition of edema as compared to the extract. A significant inhibition in the compound 48/80 induced degranulation of mast cells in dose-dependant manner (20, 40 and 80 mg/kg, po) was observed thus showing mast cell stabilizing activity. The standard disodium cromoglycate (50 mg/kg, ip) was found to demonstrate maximum per cent protection against degranulation as compared to the extract containing 60% AKBA. The results suggest promising antianaphylactic and mast cell stabilizing activity of the extract.

• Authors: Pratibha Pungle, M Banavalikar, A Suthar, M Biyani, S Mengi
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 41 Issue 12 Pg. 1460-2 (Dec 2003) ISSN: 0019-5189 [Print] India
• PMID: 15320503 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Triterpenes
• boswellic acid

Topics

• Adjuvants, Immunologic (pharmacology)
• Anaphylaxis (immunology, prevention & control)
• Animals
• Boswellia (chemistry)
• Cell Degranulation (drug effects)
• Dose-Response Relationship, Drug
• Male
• Mast Cells (drug effects)
• Rats
• Rats, Wistar
• Triterpenes (pharmacology)