Duplication 4p and deletion 4p (Wolf-Hirschhorn syndrome) due to complementary gametes from a 3:1 segregation of a maternal balanced t(4;13)(p16;q11) translocation.

Abstract	We present clinical and cytogenetic data on a family with a t(4;13)(p16;q11) translocation present in four generations. The balanced translocation resulted in one individual with monosomy 4p and one individual with trisomy 4p, due to 3:1 segregation. The male patient with trisomy 4p was fertile and transmitted the extra chromosome to his daughter.
Authors	S S Takeno, M Corbani, J A D Andrade, M de A C Smith, D Brunoni, M I Melaragno
Journal	American journal of medical genetics. Part A (Am J Med Genet A) Vol. 129A Issue 2 Pg. 180-3 (Aug 30 2004) ISSN: 1552-4825 [Print] United States
PMID	15316961 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright 2004 Wiley-Liss, Inc.
Topics	Abnormalities, Multiple (genetics) Adult Child, Preschool Chromosome Banding Chromosome Deletion Chromosome Disorders (genetics) Chromosome Segregation (genetics) Chromosomes, Human, Pair 4 (genetics) Female Humans Intellectual Disability (genetics) Karyotyping Male Pedigree Syndrome Translocation, Genetic (genetics) Trisomy (genetics)

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