Abstract | AIM: To study the teratogenicity of oral griseofulvin during pregnancy. METHODS: RESULTS: In total, 38,151 pregnant women who delivered newborn infants without any defects (control group) and 22,843 pregnant women who had fetuses or newborns with congenital abnormalities were included in the study. Seven (0.03%) case and 24 (0.06%) control pregnant women were treated with the griseofulvin (crude odds ratio with 95% confidence interval: 0.49, 0.21-1.13). A teratogenic potential of griseofulvin was not indicated by a comparison of the expected and observed number of different congenital abnormalities. A higher mean birth weight was found in control newborn infants born to mothers with griseofulvin treatment compared with the data of control newborn infants without this treatment. In addition, 55 conjoined twins were evaluated in the data set of the Hungarian Congenital Abnormality Registry, and no conjoined twins had mother with griseofulvin treatment during pregnancy. CONCLUSION: Our data do not indicate a detectable teratogenic risk of oral griseofulvin treatment during pregnancy; however, the numbers of cases and controls were limited. Therefore, international collaboration is needed for the final conclusion.
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Authors | Andrew E Czeizel, Júlia Métneki, Zoltán Kazy, Elisabeth Puho |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 83
Issue 9
Pg. 827-31
(Sep 2004)
ISSN: 0001-6349 [Print] United States |
PMID | 15315593
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antifungal Agents
- Griseofulvin
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Topics |
- Abnormalities, Drug-Induced
(diagnosis, epidemiology)
- Administration, Oral
- Adult
- Antifungal Agents
(administration & dosage, adverse effects)
- Birth Weight
- Case-Control Studies
- Confidence Intervals
- Dose-Response Relationship, Drug
- Female
- Follow-Up Studies
- Griseofulvin
(administration & dosage, adverse effects)
- Humans
- Hungary
(epidemiology)
- Incidence
- Infant, Newborn
- Odds Ratio
- Pregnancy
- Reference Values
- Registries
- Retrospective Studies
- Risk Assessment
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