Treatment of partial-thickness burns: a prospective, randomized trial using Transcyte.

Abstract

BACKGROUND:

The purpose of the present study was to compare the effectiveness of three burns dressings (TransCyte, a bio-engineered skin substitute; Biobrane; and Silvazine cream (silver sulphadiazine and 0.2% chlorhexidine)), in treating children with partial-thickness burns. The primary objective was to determine the days until > or =90% re-epithelialization. The secondary objectives were to evaluate the number of wounds requiring autografting and the number of dressing changes/local wound care required.

METHODS:

Study wounds were identified on each patient and the patients were randomized to receive TransCyte or Biobrane or Silvazine. Assessment of study wound closure began at 2 days after treatment and continued at least every other day thereafter until the wounds re-epithelialized or were autografted. A laser Doppler imaging system was used as an adjunct to assessing the depth of the burn.

RESULTS:

Thirty-three patients with 58 wound sites enrolled in the study (TransCyte, n = 20, Biobrane, n = 17; Silvazine, n = 21). Mean time to re-epithelialization was 7.5 days for TransCyte, 9.5 days for Biobrane, and 11.2 days for Silvazine. The number of wounds requiring autografting were 5/21 (24%) for Silvazine, 3/17 (17%) for Biobrane, and 1/20 (5%) for TransCyte.

CONCLUSIONS:

When used in partial-thickness burns in children, TransCyte promotes fastest re-epithelialization and required less overall dressings then Biobrane or Silvazine. Patients who received Silvazine or Biobrane require more autografting than those treated with TransCyte.

• Authors: Rohit J Kumar, Roy M Kimble, Robert Boots, Stuart P Pegg
• Journal: ANZ journal of surgery (ANZ J Surg) Vol. 74 Issue 8 Pg. 622-6 (Aug 2004) ISSN: 1445-1433 [Print] Australia
• PMID: 15315558 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents, Local
• Biobrane
• Coated Materials, Biocompatible
• Drug Combinations
• Chlorhexidine
• Silver Sulfadiazine

Topics

• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Burns (therapy)
• Child
• Child, Preschool
• Chlorhexidine (administration & dosage, therapeutic use)
• Coated Materials, Biocompatible (therapeutic use)
• Drug Administration Schedule
• Drug Combinations
• Follow-Up Studies
• Humans
• Occlusive Dressings
• Prospective Studies
• Silver Sulfadiazine (administration & dosage, therapeutic use)
• Skin Transplantation
• Skin, Artificial
• Time Factors
• Treatment Outcome
• Wound Healing (drug effects)