Abstract | BACKGROUND: MATERIALS AND METHODS: Thirty patients were divided into two groups: 15 were submitted to DSRS (Group I) and the other 15 were submitted to DSRS + SAL (Group II). They were observed for 24 months. Clinical and laboratory features were analyzed. RESULTS: There was neither mortality nor clinical manifestation of portosystemic encephalopathy in both groups. Recurrent hemorrhage and thrombosis incidence had no statistical difference. Although patients in Group II presented higher levels of postoperative pain and fever, spleen size reduction was higher than in Group I. White blood cells and platelets were increased in patients who underwent DSRS + SAL, even though there was no statistically significant difference between the groups. An increase in bilirubin was observed on the first postoperative day. Arterial blood ammonia and liver function were similar in both groups. Endoscopic control showed reduction in size of varices or their disappearance in 80 and 93% of patients from Groups I and II, respectively. CONCLUSIONS: Although SAL associated with DSRS was responsible for increasing postoperative morbidity, it did not increase the incidence of shunt thrombosis and improved white blood cells and platelets count as well as reduced the spleen size. Therefore, the authors believe that SAL associated with DSRS is an effective treatment for schistosomal portal hypertension. Besides, it should be performed when a large spleen and hypersplenism are present.
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Authors | Valdinaldo A Melo, Gustavo B Melo, Reginaldo Ceneviva |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 121
Issue 1
Pg. 108-11
(Sep 2004)
ISSN: 0022-4804 [Print] United States |
PMID | 15313383
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Humans
- Hypertension, Portal
(surgery)
- Ligation
- Prospective Studies
- Schistosomiasis
(complications)
- Splenic Artery
(surgery)
- Splenorenal Shunt, Surgical
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