Interferon-induced remission of rapidly growing aggressive fibromatosis in the temporal fossa.

Abstract

Aggressive fibromatosis is the name for uncommon soft-tissue neoplasms arising within musculoaponeurotic tissue. They show benign histologic features but have an aggressive local behaviour and frequently recur after surgery or radiation. A 48-year-old black woman presented with recurrent aggressive fibromatosis after primary radiotherapy in the left temporal fossa involving the base of the skull. The patient received interferon alpha2a subcutaneously for 6 months. A slow but steady reduction of the tumour was observed, and pre-existing symptoms disappeared.

• Authors: J-D Raguse, H J Gath, H Oettle, J Bier
• Journal: International journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 33 Issue 6 Pg. 606-9 (Sep 2004) ISSN: 0901-5027 [Print] Denmark
• PMID: 15308262 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins

Topics

• Antineoplastic Agents (administration & dosage)
• Female
• Fibromatosis, Aggressive (drug therapy, pathology)
• Head and Neck Neoplasms (drug therapy, pathology)
• Humans
• Injections, Subcutaneous
• Interferon alpha-2
• Interferon-alpha (administration & dosage)
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local
• Recombinant Proteins