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[Preliminary study on alternative half body irradiation in the treatment of hematological malignancies].

AbstractOBJECTIVE:
To evaluate the curative effect of alternative half body irradiation (AHBI) in the treatment of hematological malignancies.
METHODS:
Seventeen patients with hematological malignancies in complete remission received a high-dose chemotherapy, followed by a two-step AHBI on day 14 (12 approximately 22), upper (UHBI) and lower half body irradiation (LHBI) were sequentially given with each a single dose of 6 approximately 9 Gy at an interval of 23 (7 approximately 34) days. Fourteen received autologous hematopoietic stem cell transplantation (AHSCT) during the same period were chosen as control.
RESULTS:
Hematopoiesis recovery was observed in all the AHBI patients. The 3-year disease free survival (DFS) rate and the AHBI-related mortality were (52.38 +/- 13.47)% and 0, respectively. The longest survival time was 1446 days with a median follow-up period of 927 (428 approximately 1446) days. The 3-year DFS for the 11 acute lymphocytic leukemia (ALL) patients was (47.73 +/- 17.55)%. By contrast, the 3-year DFS and the AHSCT-related mortality for the 14 ALL patients in the control AHSCT group were (53.88 +/- 14.08)% and 14%, respectively. There was no significant difference in 3-year DFS between AHBI and AHSCT ALL patients.
CONCLUSIONS:
AHBI provides a feasible approach for hematological malignancy patients.
AuthorsJia-Lin Wei, Mei Wang, De-Hui Zou, Dong-Lin Yang, Rui Li, Jun Ning, Si-Zhou Feng, Ming-Zhe Han
JournalZhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi (Zhonghua Xue Ye Xue Za Zhi) Vol. 25 Issue 6 Pg. 355-8 (Jun 2004) ISSN: 0253-2727 [Print] China
PMID15308016 (Publication Type: English Abstract, Journal Article)
Topics
  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Female
  • Hematologic Neoplasms (drug therapy, radiotherapy)
  • Hemibody Irradiation (adverse effects, methods)
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome

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