[Clinical observation on effect of Yiqi Yangyin Huoxue Tongfu principle in treating diabetes mellitus type 2 of secondary failure to sulfonylurea agents].

Abstract

OBJECTIVE:

To observe the effect of Yiqi Yangyin Huoxue Tongfu (YYHT) principle in treating diabetes mellitus type 2 of secondary failure to sulfonylurea agents.

METHODS:

Forty patients were randomly divided into two groups, based on the unchanged previous treatment of sulfonylurea agents, Chinese decoction prescribed according to YYHT principle was given to the treated group and rosiglitazone was given to the control group. Changes of insulin sensitivity (SI), insulin response to glucose (IRG), insulin sensitive index (ISI), tumor necrosis factor-alpha (TNF-alpha), endothelin-1 (ET-1), 6-keto-prostaglandin F1alpha(6-keto-PGF1alpha) and thromboxane B2 (TXB2) were observed.

RESULTS:

The total effective rate in the treated group was 71.4%, that on improving peripheral insulin resistance was 76.2%, the two parameters were similar to those in the control group. In the treated group, SI, ISI were significantly improved, and TNF-alpha, ET-1 and TXB2 significantly lowered, but no change of IRR was found.

CONCLUSION:

Application of YYHT principle in treating patients with diabetes mellitus type 2 of secondary failure to sulfonylurea agents could alleviate the peripheral resistance to insulin, inhibit TNF-alpha, and protect the vascular endothelial cells.

• Authors: Ping Chen, Zhang-zhi Zhu, Jiang-ming Lang, Aisheng Wei, Fasheng Chen
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 24 Issue 7 Pg. 585-8 (Jul 2004) ISSN: 1003-5370 [Print] China
• PMID: 15307693 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Drugs, Chinese Herbal
• Endothelin-1
• Hypoglycemic Agents
• Sulfonylurea Compounds
• Tumor Necrosis Factor-alpha

Topics

• Adult
• Aged
• Diabetes Mellitus, Type 2 (drug therapy)
• Drugs, Chinese Herbal (therapeutic use)
• Endothelin-1 (metabolism)
• Female
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin Resistance
• Male
• Middle Aged
• Phytotherapy
• Sulfonylurea Compounds (therapeutic use)
• Tumor Necrosis Factor-alpha (metabolism)
• Yin Deficiency (drug therapy)