Effect of splenectomy on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma.

Abstract

UNLABELLED:

The investigation of 400 adult mice had the objective to find out 1. The influence of splenectomy on genesis and growth of a benzpyrene-induced sarcoma and 2. The behavior of B- and T-lymphocytes under the influence of splenectomy.

RESULTS:

1. A significantly lower number of tumors developed in splenectomized animals (28.5%) as compared to controls (49.5%). 2. A significant decrease of B-lymphocytes and an increase in T cells after splenectomy were found in the peripheral blood. 3. The examination of the tumor marginal zone showed a decreased number of B-lymphocytes and an increase of T-lymphocytes, while the total count of round cells remained unchanged. These results are discussed and compared with results of other authors.

• Authors: C Witting, E Hultsch
• Journal: Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology (Z Krebsforsch Klin Onkol Cancer Res Clin Oncol) Vol. 92 Issue 3 Pg. 267-74 (Oct 30 1978) ISSN: 0084-5353 [Print] Germany
• PMID: 153068 (Publication Type: Journal Article)

Chemical References

• Benzopyrenes

Topics

• Animals
• B-Lymphocytes (immunology)
• Benzopyrenes
• Female
• Mice
• Myosarcoma (immunology, pathology)
• Sarcoma, Experimental (immunology, pathology)
• Splenectomy
• T-Lymphocytes (immunology)