Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with retinitis pigmentosa.

Abstract

OBJECTIVE:

To report the subjective and objective improvement in vision in a patient with autosomal dominant retinitis pigmentosa after transplantation of a sheet of fetal neural retina together with its retinal pigment epithelium.

DESIGN:

A sheet of fetal neural retina with its retinal pigment epithelium was transplanted into the subretinal space under the fovea unilaterally in a patient with retinitis pigmentosa with visual acuity of 20/800 in the treated eye. Early Treatment Diabetic Retinopathy Study visual acuity testing, scanning laser ophthalmoscope, tissue typing of the donor and recipient, fluorescein angiography, multifocal electroretinogram, multifocal visually evoked potential, and clinical examination were used.

RESULTS:

No clinical evidence of rejection was observed. There was no retinal edema or scarring. The transplant sheet lost its pigmentation by 6 months.

MAIN OUTCOME MEASURES:

A change in visual acuity from 20/800 to 20/400 (7 months), 20/250 (9 months), and 20/160 (1 year) was observed by Early Treatment Diabetic Retinopathy Study visual acuity testing. Independently, scanning laser ophthalmoscope testing at a different institution at 9 months showed a visual acuity of 20/270 at a 40 degrees field of view.

CONCLUSION:

This study indicates that fetal retina transplanted with its retinal pigment epithelium can survive 1 year without apparent clinical evidence of rejection and show continued improvement in Early Treatment Diabetic Retinopathy Study visual acuity.

• Authors: Norman D Radtke, Robert B Aramant, Magdalene J Seiler, Heywood M Petry, Diane Pidwell
• Journal: Archives of ophthalmology (Chicago, Ill. : 1960) (Arch Ophthalmol) Vol. 122 Issue 8 Pg. 1159-65 (Aug 2004) ISSN: 0003-9950 [Print] United States
• PMID: 15302656 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Electroretinography
• Evoked Potentials, Visual
• Female
• Fetal Tissue Transplantation
• Fluorescein Angiography
• Genes, Dominant
• Graft Survival (physiology)
• Histocompatibility Testing
• Humans
• Middle Aged
• Ophthalmoscopy
• Pigment Epithelium of Eye (physiology, transplantation)
• Retina (physiology, transplantation)
• Retinitis Pigmentosa (genetics, physiopathology, surgery)
• Vision, Ocular (physiology)
• Visual Acuity (physiology)