Vanadyl sulfate ameliorates insulin resistance and restores plasma dehydroepiandrosterone-sulfate levels in fructose-fed, insulin-resistant rats.

Abstract

OBJECTIVES:

To elucidate whether vanadyl sulfate ameliorates the decreased dehydroepiandrosterone sulfate (DHEAS) in hyperinsulinemic rats, we evaluated plasma DHEAS, insulin and triglyceride (TG) levels in fructose-induced, insulin-resistant rats.

DESIGN AND METHODS:

Animals were divided into three groups: control (C), fructose fed (F-F), and vanadyl-treated fructose fed (F-T). Control animals were fed with standard chow; F-F and F-T groups fed with 66% fructose diet. F-F and C groups received tap water; F-T group received water supplemented with 0.2 mg/ml vanadyl sulfate.

RESULTS:

Fasting plasma glucose levels of three groups were comparable. Vanadyl treatment prevented the increase in plasma insulin and TG in the F-T group (P < 0.001) compared with the F-F group. Fructose feeding led to a decrease in plasma DHEAS in the F-F group (P < 0.001) compared with the C group. Vanadyl treatment prevented the decrease in plasma DHEAS in the F-T group (P < 0.001) compared with the F-F group.

CONCLUSIONS:

Our results indicated that the hyperinsulinemia in fructose-fed, insulin-resistant rats is associated with low levels of DHEAS. Vanadyl sulfate probably restores plasma DHEAS, due to the improved insulin action.

• Authors: Mehdi Harati, Mohsen Ani
• Journal: Clinical biochemistry (Clin Biochem) Vol. 37 Issue 8 Pg. 694-7 (Aug 2004) ISSN: 0009-9120 [Print] United States
• PMID: 15302613 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Hypoglycemic Agents
• Insulin
• Triglycerides
• Vanadium Compounds
• Fructose
• Dehydroepiandrosterone Sulfate
• vanadyl sulfate

Topics

• Animals
• Blood Glucose (biosynthesis)
• Dehydroepiandrosterone Sulfate (blood)
• Fructose (metabolism)
• Hyperinsulinism (metabolism)
• Hypertriglyceridemia (blood, drug therapy)
• Hypoglycemic Agents (pharmacology)
• Insulin (metabolism)
• Insulin Resistance
• Male
• Models, Statistical
• Rats
• Rats, Wistar
• Triglycerides (metabolism)
• Vanadium Compounds (pharmacology)