Abstract | OBJECTIVE: METHODS: Semi-quantitative reverse transcription-PCR (RT-PCR) was used to detect and quantify the mRNAs of RAMP1 and RAMP3 in the atria of heart failing patients. RESULTS: It was found that the expressions of RAMP1, RAMP2 and RAMP3 mRNAs increased with the worsening of heart function, but the expressions of RAMP1 and RAMP2 mRNA decreased at level IV of heart failure. CONCLUSION: The above results demonstrated in the atria of heart failure patients an up-regulation of CGRP receptor by an increase of RAMP1 in association with CRLR and an up-regulation of ADM receptor by an increase of RAMP2 expression in association with CRLR, thus suggesting that CGRP and ADM receptors be playing a functional role in compensating the chronic heart failure in human.
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Authors | Yu-fang Wang, Ji Zhang, Jing Li, Li-qiong Lan, Zhi-mei Yang, Shu-ren Wang |
Journal | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
(Zhonghua Yi Xue Yi Chuan Xue Za Zhi)
Vol. 21
Issue 4
Pg. 351-4
(Aug 2004)
ISSN: 1003-9406 [Print] China |
PMID | 15300632
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- CALCRL protein, human
- Calcitonin Receptor-Like Protein
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- RAMP1 protein, human
- RAMP2 protein, human
- RAMP3 protein, human
- Receptor Activity-Modifying Protein 1
- Receptor Activity-Modifying Protein 2
- Receptor Activity-Modifying Protein 3
- Receptor Activity-Modifying Proteins
- Receptors, Adrenomedullin
- Receptors, Calcitonin
- Receptors, Calcitonin Gene-Related Peptide
- Receptors, Peptide
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Topics |
- Adult
- Calcitonin Receptor-Like Protein
- Female
- Heart Atria
(metabolism)
- Heart Failure
(genetics, physiopathology)
- Humans
- Intracellular Signaling Peptides and Proteins
(genetics, physiology)
- Male
- Membrane Proteins
(genetics, physiology)
- Receptor Activity-Modifying Protein 1
- Receptor Activity-Modifying Protein 2
- Receptor Activity-Modifying Protein 3
- Receptor Activity-Modifying Proteins
- Receptors, Adrenomedullin
- Receptors, Calcitonin
(genetics, physiology)
- Receptors, Calcitonin Gene-Related Peptide
(genetics, physiology)
- Receptors, Peptide
(genetics, physiology)
- Reverse Transcriptase Polymerase Chain Reaction
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