Protective effects of barley and its hydrolysates on gastric stress ulcer in rats.
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| Abstract |
This research intends to clarify the protective effect of barley and its hydrolysates with respect to a water immersion stress-induced ulcer in the rat model. The beta-(1-->3)-glucan content of barley, and specifically beta-(1-->4),(1-->3)-glucan content was determined and then gastric stress ulcerogenesis induced by water immersion was conducted using five-week-old male Sprague-Dawley rats (7 rats in one group). The barley diet group was fed 10% barley flour that was substituted with sucrose in the control diet. For the 3 groups fed on soluble dietary fiber (SDF), the diets were supplemented with 0.46 g of SDF, equivalent to 100 g of the control diet; 0.46 g of SDF is equivalent to 10 g of barley flour. The rats were housed in a stress-cage and immersed in a water bath (23 degrees C) up to their necks for 21 h. The content of SDF and beta-(1-->3)-glucan content in barley flour were 4.6% and 3.4%, respectively. Although strongly anti-ulcer activities were observed in the barley (10%), SDF isolated and beta-(1-->3)-glucan fraction (Hydrolysate I) prepared from barley flour after treatment with lichenase, in other words, beta-(1-->4),(1-->3)-glucan itself, its hydrolysate (Hydrolysate II) with beta-(1-->3)-glucosidase did not display any anti-ulcer activity. This finding suggests that the beta-(1-->3)-glucosyl-linkage on beta-(1-->3)-glucan is an important part of the active principle for anti-ulcerogenesis.
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| Authors | Minako Yoshizawa, Komaki Yokoyama, Yoshihisa Nakano, Hisao Nakamura |
| Journal | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (Yakugaku Zasshi) Vol. 124 Issue 8 Pg. 571-5 (Aug 2004) ISSN: 0031-6903 [Print] Japan |
| PMID | 15297727 (Publication Type: Journal Article) |
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