Outcome of uterine embolization and hysterectomy for leiomyomas: results of a multicenter study.

Abstract

OBJECTIVE:

The purpose of this study was to estimate the outcomes of uterine embolization and hysterectomy for uterine leiomyomas. Study design This was a multicenter prospective study of patients who were treated with embolization (n=102 patients) and hysterectomy (n=50 patients) for leiomyomas. Changes in symptoms, complications, and quality of life were measured. The data analysis included linear and logistic regression, the Student t and paired t test, Fisher's exact test, and chi-squared test.

RESULTS:

For patients who underwent embolization, there were marked reductions in blood loss scores (P <.001) and menorrhagia questionnaire scores (P <.001) compared with baseline. At 12 months, a larger proportion of the patients who had undergone hysterectomy experienced improved pelvic pain (P=.021). Both groups had marked improvement in other symptoms and quality of life scores, with no difference between groups. Complications were more frequent in patients who underwent hysterectomy (50% vs 27.5%; P=.01).

CONCLUSION:

Both procedures substantially improved symptoms for most patients, with an advantage for hysterectomy at 12 months for pelvic pain. Serious complications were infrequent in both groups.

• Authors: James B Spies, Jay M Cooper, Robert Worthington-Kirsch, John C Lipman, Benjie B Mills, James F Benenati
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 191 Issue 1 Pg. 22-31 (Jul 2004) ISSN: 0002-9378 [Print] United States
• PMID: 15295340 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Arteries
• Embolization, Therapeutic (adverse effects)
• Female
• Health Status Indicators
• Humans
• Hysterectomy (adverse effects)
• Leiomyoma (blood supply, surgery, therapy)
• Logistic Models
• Microspheres
• Middle Aged
• Quality of Life
• Treatment Outcome
• Uterine Neoplasms (blood supply, surgery, therapy)
• Uterus (blood supply)