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Protease expression in interface tissues around loose arthroplasties.

Abstract
To determine whether cathepsins and matrix metalloproteinase-1 are involved in accelerating tissue destruction, we examined, immunohistochemically, the expression of matrix metalloproteinase-1 and cathepsins B, D, L, and X in periprosthetic synovial-like interface tissues from 14 patients with failed prosthetic hips and in the synovial membranes of hips from 18 patients with rheumatoid arthritis and 25 patients with primary osteoarthritis. The expression levels of all these proteases in the interface tissue were higher than in the synovial membrane of osteoarthritis. The expression levels of cathepsins B and X in the interface tissue were higher than in the rheumatoid synovium. The results show similarities in the expression patterns of cathepsins D and L and matrix metalloproteinase-1 between aseptic prosthetic loosening and rheumatoid arthritis. In addition, these data suggest that the impact of cathepsins B and X on tissue degradation is more pronounced in aseptic prosthetic loosening than in rheumatoid arthritis.
AuthorsA Kido, G Pap, D K Nägler, E Ziomek, R Ménard, H W Neumann, A Roessner
JournalClinical orthopaedics and related research (Clin Orthop Relat Res) Issue 425 Pg. 230-6 (Aug 2004) ISSN: 0009-921X [Print] United States
PMID15292813 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cathepsins
  • Metalloendopeptidases
Topics
  • Aged
  • Arthritis, Rheumatoid (metabolism, surgery)
  • Cathepsins (metabolism)
  • Female
  • Hip Prosthesis
  • Humans
  • Immunohistochemistry
  • Male
  • Metalloendopeptidases (metabolism)
  • Middle Aged
  • Osteoarthritis (metabolism, surgery)
  • Prosthesis Failure
  • Reoperation

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