Abstract |
The cytotoxicity (in the dark), phototoxicity (red light) and subcellular localization (using confocal laser scanning microscopy) were determined for 15 porphyrins (1-15) in C6 glioma cells. The partition coefficient in 2-octanol was also determined for each porphyrin at pH 7.4. The cytotoxicity increased with pi (log of partition coefficient) up to pi values of +2. The 7 porphyrins with cationic side chains exhibited a classical parabolic correlation between phototoxicity and pi, with maximal activity at a pi value of approximately 1.0. There was also a significant correlation between subcellular localization and degree of phototoxicity, with the three most photosensitive porphyrins all possessing cationic side chains, and all three localizing in mitochondria.
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Authors | K W Woodburn, N J Vardaxis, J S Hill, A H Kaye, J A Reiss, D R Phillips |
Journal | Photochemistry and photobiology
(Photochem Photobiol)
Vol. 55
Issue 5
Pg. 697-704
(May 1992)
ISSN: 0031-8655 [Print] United States |
PMID | 1528983
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Cell Survival
(drug effects)
- Photochemistry
- Photochemotherapy
- Porphyrins
(chemistry, pharmacokinetics, pharmacology)
- Structure-Activity Relationship
- Tumor Cells, Cultured
(drug effects, metabolism)
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