[Radioprotective capacity of indralin in reducing radiation injury to salivary glands].

Abstract

Radioprotective capacity of radioprotector indraline (alpha-1(B)-adrenoagonist) was studied by its effect on early displays of a local radiation injury to salivary glands in white rats after X-ray irradiation of an animal head with a dose of 18.7 Gy. Indraline was found to be capable to reduce a radiation injury to parotid glands registered by reduction of gland mass on 6th day after irradiation. In experiments on rats, radioprotective efficiency of indraline (100 mg/kg) in term of DRF is close to 1.5.

• Authors: M V Vasin, I B Ushakov, E P Korovkina, V Iu Kovtun
• Journal: Radiatsionnaia biologiia, radioecologiia (Radiats Biol Radioecol) 2004 May-Jun Vol. 44 Issue 3 Pg. 333-5 ISSN: 0869-8031 [Print] Russia (Federation)
• Vernacular Title: Protivoluchevye svoĭstva indralina po snizheniiu tiazhesti luchevogo porazheniia sliunnykh zhelez.
• PMID: 15287265 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phenols
• Radiation-Protective Agents
• indralin

Topics

• Animals
• Female
• Organ Size (drug effects, radiation effects)
• Phenols (pharmacology)
• Radiation Injuries, Experimental (etiology, prevention & control)
• Radiation-Protective Agents (pharmacology)
• Rats
• Salivary Glands (radiation effects)