Physiological, pharmacokinetic, and pharmacodynamic changes in space.

Abstract

Medications have been taken since the first Mercury flight in 1967 and, since then, have been used for several indications such as space motion sickness, sleeplessness, headache, nausea, vomiting, back pain, and congestion. As the duration of space missions get longer, it is even more likely that astronauts will encounter some of the acute illnesses that are frequently seen on Earth. Microgravity environment induces several physiological changes in the human body. These changes include cardiovascular degeneration, bone decalcification, decreased plasma volume, blood flow, lymphocyte and eosinophil levels, altered hormonal and electrolyte levels, muscle atrophy, decreased blood cell mass, increased immunoglobulin A and M levels, and a decrease in the amount of microsomal P-450 and the activity of some of its dependent enzymes. These changes may be expected to have severe implications on the pharmacokinetic and pharmacodynamic properties of drug substances.

• Authors: Annemarie Graebe, Edgar L Schuck, Petra Lensing, Lakshmi Putcha, Hartmut Derendorf
• Journal: Journal of clinical pharmacology (J Clin Pharmacol) Vol. 44 Issue 8 Pg. 837-53 (Aug 2004) ISSN: 0091-2700 [Print] England
• PMID: 15286087 (Publication Type: Journal Article, Review)

Chemical References

• Enzymes
• Hormones
• Pharmaceutical Preparations
• Sodium

Topics

• Aerospace Medicine
• Body Water (physiology)
• Bone Demineralization, Pathologic
• Cardiovascular Physiological Phenomena
• Enzymes (metabolism)
• Erythrocyte Count
• Female
• Hemodynamics
• Hormones (metabolism)
• Humans
• Immunity
• Kidney (blood supply, physiology)
• Male
• Muscular Atrophy
• Pharmaceutical Preparations
• Pharmacokinetics
• Sex Factors
• Sodium (metabolism)
• Space Flight
• Time Factors
• Weightlessness