New fascaplysin-based CDK4-specific inhibitors: design, synthesis and biological activity.

Abstract

The first biologically active non-planar analogues of the toxic anti-cancer agent, fascaplysin, have been produced; we present the design, synthesis and biological activity of three tryptamine derivatives.

• Authors: Carine Aubry, Paul R Jenkins, Sachin Mahale, Bhabatosh Chaudhuri, Jean-Didier Maréchal, Michael J Sutcliffe
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Issue 15 Pg. 1696-7 (Aug 07 2004) ISSN: 1359-7345 [Print] England
• PMID: 15278142 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Enzyme Inhibitors
• Indoles
• Proto-Oncogene Proteins
• fascaplysine
• Cyclin-Dependent Kinase 4
• Cyclin-Dependent Kinases
• Tyramine

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cyclin-Dependent Kinase 4
• Cyclin-Dependent Kinases (antagonists & inhibitors)
• Enzyme Inhibitors (chemical synthesis, chemistry, pharmacology)
• Indoles (chemical synthesis, chemistry, pharmacology)
• Models, Molecular
• Proto-Oncogene Proteins (antagonists & inhibitors)
• Tyramine (analogs & derivatives, chemical synthesis, chemistry)