| Abstract | The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs. |
| Authors | Caterina Cerminara, Maria Lucia Montanaro, Paolo Curatolo, Stefano Seri
(Affiliation: Department of Developmental Neurology and Psychiatry, Division of Neurosciences, Tor Vergata University, Rome, Italy.)
|
| Journal | Neurology
(Neurology)
Vol. 63
Issue 2
Pg. 373-5
(Jul 27 2004)
ISSN: 1526-632X United States |
| PMID | 15277643
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Anticonvulsants
- Triazines
- lamotrigine
- Valproic Acid
|
| Topics |
- Anticonvulsants
(adverse effects, therapeutic use)
- Child
- Drug Therapy, Combination
- Electroencephalography
(drug effects)
- Electromyography
- Epilepsy, Rolandic
(drug therapy, physiopathology)
- Female
- Humans
- Myoclonus
(chemically induced)
- Seizures
(chemically induced)
- Sleep Disorders, Intrinsic
(drug therapy, physiopathology)
- Triazines
(adverse effects, therapeutic use)
- Valproic Acid
(therapeutic use)
|
