Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis.

Abstract

BACKGROUND:

KC 11458, a motilin agonist without antibiotic properties, accelerates gastric emptying in animals and healthy humans.

AIM:

To evaluate the acute effects of KC 11458 on gastric emptying in diabetic gastroparesis.

METHODS:

Twenty-nine patients (6 type 1 and 23 type 2) with gastroparesis underwent assessments of: (i) gastric emptying of a solid/liquid meal using scintigraphy, (ii) glycaemic control (blood glucose at 0, 30, 60, 90 and 120 min during the gastric emptying measurement) and (iii) upper gastrointestinal and 'meal-related' symptoms (questionnaire), at baseline and after treatment with KC 11458 in a dose of 8 mg t.d.s., or placebo for 8 days.

RESULTS:

KC 11458 had no statistically significant or clinically relevant effect on gastric emptying of either the solid intragastric retention at 100 min (T100) (P = 0.87) or liquid 50% emptying time (T50) (P = 0.17) components of the meal. KC 11458 slightly worsened (P = 0.04) upper gastrointestinal symptoms when compared with placebo. The magnitude of the change in solid gastric emptying correlated with the change in the blood glucose concentration (r = 0.49; P < 0.05).

CONCLUSIONS:

KC 11458, in a dose of 8 mg t.d.s. for 8 days, does not accelerate gastric emptying in patients with diabetic gastroparesis. The absence of efficacy may relate to an effect of hyperglycaemia.

• Authors: A Russo, J E Stevens, N Giles, G Krause, D G O'Donovan, M Horowitz, K L Jones
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 20 Issue 3 Pg. 333-8 (Aug 01 2004) ISSN: 0269-2813 [Print] England
• PMID: 15274670 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• KC 11458
• Motilin
• Erythromycin

Topics

• Autonomic Nervous System Diseases (blood, physiopathology)
• Blood Glucose (metabolism)
• Diabetes Mellitus (blood, physiopathology)
• Diabetic Neuropathies (blood, physiopathology)
• Erythromycin (analogs & derivatives, pharmacology)
• Female
• Gastric Emptying (drug effects)
• Gastroparesis (blood, physiopathology)
• Humans
• Male
• Middle Aged
• Motilin (antagonists & inhibitors)