Abstract | BACKGROUND: MATERIALS AND METHODS: Sections from formalin-fixed, paraffin-embedded samples of ONM, OPL or OSCC were examined using immunohistochemical staining to detect L4T1 and 4F2hc proteins. RESULTS: The LAT1 and 4F2hc expression increased progressively from ONM to hyperplastic and to dysplastic lesions and OSCC. In particular, LAT1 may be a more specific indicator of tumor progression than 4F2hc. CONCLUSION: LAT1 and 4F2hc may have an important role in the early stages of multistep oral carcinogenesis. In addition, the specific inhibition of LAT1 and 4F2hc might be a new rationale to suppress oral cancer progression.
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Authors | Do Kyung Kim, Sang Gun Ahn, Joo Cheol Park, Yoshikatsu Kanai, Hitoshi Endou, Jung Hoon Yoon |
Journal | Anticancer research
(Anticancer Res)
2004 May-Jun
Vol. 24
Issue 3a
Pg. 1671-5
ISSN: 0250-7005 [Print] Greece |
PMID | 15274339
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fusion Regulatory Protein 1, Heavy Chain
- Large Neutral Amino Acid-Transporter 1
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Topics |
- Adult
- Aged
- Carcinoma, Squamous Cell
(metabolism, pathology)
- Female
- Fusion Regulatory Protein 1, Heavy Chain
(biosynthesis)
- Humans
- Large Neutral Amino Acid-Transporter 1
(biosynthesis)
- Male
- Middle Aged
- Mouth Mucosa
(metabolism)
- Mouth Neoplasms
(metabolism, pathology)
- Paraffin Embedding
- Precancerous Conditions
(metabolism)
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