Abstract | AIM: To estimate the selectivity of action of cobalt complexes on tumor tissue. MATERIALS AND METHODS: RESULTS: A significant and selective increase of malondialdehyde in tumor tissue reflecting activation of lipid peroxidation was found after administration of the complexes. The bioenergetic status in tumor was also selectively affected by the complexes: minimization of signals of high-energy phosphates was observed two hours after injection of the complexes. An increase of the number of DNA single-strand breaks was registered in tumor tissue, supporting the suggestion that the complexes may directly affect DNA. A correlation between the above tumor effects and the structure of axial ligands was demonstrated. CONCLUSION:
Cobalt(III) complexes affect tumor tissue with a very high level of selectivity; in particular they activate lipid peroxidation, induce DNA single-strand breaks, suppress the bioenergetic status, and enhance hypoxia. It is supposed that the selective action of these complexes on tumor tissue is due to peculiarities of tumor microphysiology, in particular significant tumor hypoxia.
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Authors | Sergey Osinsky, Ilia Levitin, Larissa Bubnovskaya, Andrey Sigan, Irina Ganusevich, Antonina Kovelskaya, Natalya Valkovskaya, Luigi Campanella, Peter Wardman |
Journal | Experimental oncology
(Exp Oncol)
Vol. 26
Issue 2
Pg. 140-4
(Jun 2004)
ISSN: 1812-9269 [Print] Ukraine |
PMID | 15273664
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ethylenediamines
- Ligands
- Pentanones
- Niacinamide
- Niacin
- Cobalt
- acetylacetone
- isonicotinamide
- Malondialdehyde
- ethylenediamine
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Topics |
- Adenocarcinoma
(metabolism, pathology)
- Animals
- Carcinoma, Lewis Lung
(metabolism, pathology)
- Cobalt
(therapeutic use)
- DNA Damage
(drug effects)
- Ethylenediamines
(metabolism, pharmacology)
- Female
- Hypoxia
- Ligands
- Lipid Peroxidation
- Malondialdehyde
(metabolism)
- Mammary Neoplasms, Experimental
(metabolism, pathology)
- Melanoma, Experimental
(metabolism, pathology)
- Mice
- Mice, Inbred C57BL
- Niacin
(metabolism, pharmacology)
- Niacinamide
(metabolism, pharmacology)
- Oxidation-Reduction
- Pentanones
(metabolism, pharmacology)
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