Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides.

Abstract

The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.

• Authors: Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Giuseppina D'Amato, Wojciech Kamysz, Federico Mocchegiani, Valerio Sisti, Carmela Silvestri, Jerzy Łukasiak, Marco Rocchi, Vittorio Saba, Giorgio Scalise
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 48 Issue 8 Pg. 3162-4 (Aug 2004) ISSN: 0066-4804 [Print] United States
• PMID: 15273140 (Publication Type: Journal Article)

Chemical References

• Acetamides
• Anti-Infective Agents
• Antimicrobial Cationic Peptides
• Glycopeptides
• Oxazolidinones
• Pharmaceutical Solutions
• Polyethylene Terephthalates
• Proteins
• temporin
• Linezolid

Topics

• Acetamides (administration & dosage, therapeutic use)
• Animals
• Anti-Infective Agents (administration & dosage, therapeutic use)
• Antimicrobial Cationic Peptides
• Blood Vessel Prosthesis
• Colony Count, Microbial
• Drug Resistance, Bacterial
• Drug Synergism
• Glycopeptides (pharmacology)
• Linezolid
• Male
• Microbial Sensitivity Tests
• Oxazolidinones (administration & dosage, therapeutic use)
• Pharmaceutical Solutions
• Polyethylene Terephthalates
• Prosthesis-Related Infections (microbiology, prevention & control)
• Proteins (administration & dosage, therapeutic use)
• Rats
• Staphylococcal Infections (microbiology, prevention & control)
• Staphylococcus epidermidis